Article
Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis.
PloS one - 1 Jan 2016
Lapérine Olivier, Cloitre Alexandra, Caillon Jocelyne, Huck Olivier, Bugueno Isaac Maximiliano, Pilet Paul, Sourice Sophie, Le Tilly Elodie, Palmer Gaby, Davideau Jean-Luc, Geoffroy Valérie, Guicheux Jérôme, Beck-Cormier Sarah, Lesclous Philippe
Abstract excerpt
INTRODUCTION: Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L....
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