Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

17 Aug 2016

Abstract excerpt

The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processing events. We recently demonstrated that a new class of human U1-like snRNAs, the variant (v)U1 snRNAs (vU1s), also participate in pre-mRNA processing events. In this study, we show that several human vU1 genes are specifically upregulated in stem cells and participate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27536002
DOI: 10.1093/nar/gkw711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular diseasePMID 27536002Read ↗

Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cellsSemantic proximity Read ↗

An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects.Semantic proximity Read ↗

Improvement of SMN2 Pre-mRNA Processing Mediated by Exon-Specific U1 Small Nuclear RNASemantic proximity Read ↗

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent intronsSemantic proximity Read ↗

Beyond housekeeping: snRNA diversity, regulation, and human disease.Semantic proximity Read ↗

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruptionSemantic proximity Read ↗

Therapeutic activity of modified U1 core spliceosomal particles.Semantic proximity Read ↗

SMN in spinal muscular atrophy and snRNP biogenesisSemantic proximity Read ↗

Development of Engineered-U1 snRNA Therapies: Current Status.Semantic proximity Read ↗

<i>De novo</i>variants in the non-coding spliceosomal snRNA gene<i>RNU4-2</i>are a frequent cause of syndromic neurodevelopmental disordersSemantic proximity Read ↗

The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP ProteinsSemantic proximity Read ↗

Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.