Article
TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.
Oncotarget - 6 Sept 2016
Venkatesan Subramanian, Hoogstraat Marlous, Caljouw Ester, Pierson Tessa, Spoor Jochem K H, Zeneyedpour Lona, Dubbink Hendrikus J, Dekker Lennard J, van der Kaaij Mariëlle, Kloezeman Jenneke, Berghauser Pont Lotte M E, Besselink Nicolle J M, Luider Theo M, Joore Jos, Martens John W, Lamfers Martine L M, Sleijfer Stefan, Leenstra Sieger
Abstract excerpt
BACKGROUND: Glioblastoma is the most malignant tumor of the central nervous system and still lacks effective treatment. This study explores mutational biomarkers of 11 drugs targeting either the RTK/Ras/PI3K, the p53 or the Rb pathway using 25 patient-derived glioblastoma stem-like cell cultures (GSCs). RESULTS: We found that TP53 mutated GSCs were approximately 3.5 fold more sensitive to dual inhibition of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.