Article
CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation.
Blood - 27 Oct 2016
Lamers Cor H J, Wijers Rebecca, van Bergen Cornelis A M, Somers Judith A E, Braakman Eric, Gratama Jan Willem, Debets Reno, Falkenburg J H Frederik, Cornelissen Jan J
Abstract excerpt
Although double umbilical cord blood transplantation (dUCBT) in adult patients may be associated with less graft failure compared with single UCBT, hematopoietic recovery generally originates from a single cord blood unit (CBU). CBU predominance is still incompletely understood. We recently showed that blood CD4+ T-cell numbers rapidly increase after dUCBT, and early CD4+ T-cell chimerism predicts for graft...
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