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Article

Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation.

PloS one - 1 Jan 2016

Binder Dennis, Probst Christopher, Grünberger Alexander, Hilgers Fabienne, Loeschcke Anita, Jaeger Karl-Erich, Kohlheyer Dietrich, Drepper Thomas

Abstract excerpt

Recombinant protein production is mostly realized with large-scale cultivations and monitored at the level of the entire population. Detailed knowledge of cell-to-cell variations with respect to cellular growth and product formation is limited, even though phenotypic heterogeneity may distinctly hamper overall production yields, especially for toxic or difficult-to-express proteins. Unraveling phenotypic...

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Identifiers

PMID: 27525986
DOI: 10.1371/journal.pone.0160711
PMCID: PMC4985164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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