Article
SEDS proteins are a widespread family of bacterial cell wall polymerases.
Nature - 29 Sept 2016
Meeske Alexander J, Riley Eammon P, Robins William P, Uehara Tsuyoshi, Mekalanos John J, Kahne Daniel, Walker Suzanne, Kruse Andrew C, Bernhardt Thomas G, Rudner David Z
Abstract excerpt
Elongation of rod-shaped bacteria is mediated by a dynamic peptidoglycan-synthetizing machinery called the Rod complex. Here we report that, in Bacillus subtilis, this complex is functional in the absence of all known peptidoglycan polymerases. Cells lacking these enzymes survive by inducing an envelope stress response that increases the expression of RodA, a widely conserved core component of the Rod complex....
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