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Article

Identification of the potential active site of the septal peptidoglycan polymerase FtsW.

PLoS genetics - 1 Jan 2022

Li Ying, Boes Adrien, Cui Yuanyuan, Zhao Shan, Liao Qingzhen, Gong Han, Breukink Eefjan, Lutkenhaus Joe, Terrak Mohammed, Du Shishen

Abstract excerpt

SEDS (Shape, Elongation, Division and Sporulation) proteins are widely conserved peptidoglycan (PG) glycosyltransferases that form complexes with class B penicillin-binding proteins (bPBPs, with transpeptidase activity) to synthesize PG during bacterial cell growth and division. Because of their crucial roles in bacterial morphogenesis, SEDS proteins are one of the most promising targets for the development of...

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Identifiers

PMID: 34986161
DOI: 10.1371/journal.pgen.1009993
PMCID: PMC8765783

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Identification of the potential active site of the septal peptidoglycan polymerase FtsW.PMID 34986161Read ↗

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