Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione S-transferase ϴ-subunit as a phenotypic suppressor of pmr1Δ strain, the Kluyveromyces lactis model for Hailey-Hailey disease.

Biochimica et biophysica acta - 1 Nov 2016

Ficociello G, Zanni E, Cialfi S, Aurizi C, Biolcati G, Palleschi C, Talora C, Uccelletti D

Abstract excerpt

BACKGROUND: Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is a rare, chronic and recurrent blistering disorder, histologically characterized by suprabasal acantholysis. HHD has been linked to mutations in ATP2C1, the gene encoding the human adenosine triphosphate (ATP)-powered calcium channel pump. METHODS: In this work, the genetically tractable yeast Kluyveromyces lactis has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Transporting ATPases
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Hydrogen Peroxide

Share to Keratinocytes

Share to Kluyveromyces

Share to Madin Darby Canine Kidney Cells

Share to Pemphigus, Benign Familial

Source

Identifiers

PMID: 27523793
DOI: 10.1016/j.bbamcr.2016.08.002

Genes

GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase ϴ-subunit as a phenotypic suppressor of pmr1Δ strain, the Kluyveromyces lactis model for Hailey-Hailey disease.PMID 27523793Read ↗

Hailey-Hailey disease as an orthodisease of PMR1 deficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Golgi Ca2+-ATPase KlPmr1p function is required for oxidative stress response by controlling the expression of the heat-shock element HSP60 in Kluyveromyces lactis.Semantic proximity Read ↗

Using yeast to model calcium-related diseases: example of the Hailey-Hailey disease.Semantic proximity Read ↗

Functional expression in yeast of the human secretory pathway Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease.Semantic proximity Read ↗

Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.Semantic proximity Read ↗

PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae.Semantic proximity Read ↗

Genetic and Physiological Characterization of Fructose-1,6-Bisphosphate Aldolase and Glyceraldehyde-3-Phosphate Dehydrogenase in the Crabtree-Negative Yeast Kluyveromyces lactis.Semantic proximity Read ↗

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump.Semantic proximity Read ↗

Structural and functional divergence of GDAP1 from the glutathione S-transferase superfamily.Semantic proximity Read ↗

RAG1 gene of the yeast Kluyveromyces lactis codes for a sugar transporter.Semantic proximity Read ↗

Characterization of an AP-1-like transcription factor that mediates an oxidative stress response in Kluyveromyces lactis.Semantic proximity Read ↗

Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.