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Article

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction.

G3 (Bethesda, Md.) - 13 Oct 2016

Lavinsky Joel, Ge Marshall, Crow Amanda L, Pan Calvin, Wang Juemei, Salehi Pezhman, Myint Anthony, Eskin Eleazar, Allayee Hooman, Lusis Aldons J, Friedman Rick A

Abstract excerpt

The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL). We describe the first genome-wide association study (GWAS) for NIHL in a large and well-characterized population of inbred mouse strains, known as the Hybrid Mouse Diversity Panel (HMDP). We recorded auditory brainstem response (ABR) thresholds...

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Identifiers

PMID: 27520957
DOI: 10.1534/g3.116.032516
PMCID: PMC5068943

Genes

ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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