Article
Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss.
PLoS genetics - 1 Apr 2015
Lavinsky Joel, Crow Amanda L, Pan Calvin, Wang Juemei, Aaron Ksenia A, Ho Maria K, Li Qingzhong, Salehide Pehzman, Myint Anthony, Monges-Hernadez Maya, Eskin Eleazar, Allayee Hooman, Lusis Aldons J, Friedman Rick A
Abstract excerpt
In the United States, roughly 10% of the population is exposed daily to hazardous levels of noise in the workplace. Twin studies estimate heritability for noise-induced hearing loss (NIHL) of approximately 36%, and strain specific variation in sensitivity has been demonstrated in mice. Based upon the difficulties inherent to the study of NIHL in humans, we have turned to the study of this complex trait in mice....
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