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Article

SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling.

Oncotarget - 13 Sept 2016

Gong Yi-Qing, Huang Wei, Li Ke-Ran, Liu Yuan-Yuan, Cao Guo-Fan, Cao Cong, Jiang Qin

Abstract excerpt

Excessive Ultra-violet (UV) radiation causes oxidative damages and apoptosis in retinal pigment epithelium (RPE) cells. Here we tested the potential activity of SC79, a novel small molecule activator of Akt, against the process. We showed that SC79 activated Akt in primary and established (ARPE-19 line) RPE cells. It protected RPE cells from UV damages possibly via inhibiting cell apoptosis. Akt inhibition, via...

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Source

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Identifiers

PMID: 27517753
DOI: 10.18632/oncotarget.11164
PMCID: PMC5312373

Genes

RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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