Article
Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections.
Scientific reports - 31 Aug 2017
Cheng Mengjun, Zhang Yufeng, Li Xinwei, Liang Jiaming, Hu Liyuan, Gong Pengjuan, Zhang Lei, Cai Ruopeng, Zhang Hao, Ge Jinli, Ji Yalu, Guo Zhimin, Feng Xin, Sun Changjiang, Yang Yongjun, Lei Liancheng, Han Wenyu, Gu Jingmin
Abstract excerpt
Phage-derived lysins can hydrolyse bacterial cell walls and show great potential for combating Gram-positive pathogens. In this study, the potential of LysEF-P10, a new lysin derived from a isolated Enterococcus faecalis phage EF-P10, as an alternative treatment for multidrug-resistant E. faecalis infections, was studied. LysEF-P10 shares only 61% amino acid identity with its closest homologues. Four proteins...
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