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Article

Hemophagocytic Lymphohistocytosis in the Chinese Han Population May Be Associated with an STXBP2 Gene Polymorphism.

PloS one - 1 Jan 2016

Yang Li, Tang Yang, Xiao Fang'Xi, Xiong Jie, Shen Ke'Feng, Liu Ya'Nan, Zhang Wei, Zheng Li'Chang, Zhou Jian'Feng, Xiao Min

Abstract excerpt

STUDY PURPOSE: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages. In this study, we aimed to explore the genetic factors involved in the pathogenesis of both acquired and familial type HLH. METHOD: The ION TORRENT semi-conductor sequencing method was used to sequence samples from 10...

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Source

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Identifiers

PMID: 27513731
DOI: 10.1371/journal.pone.0159454
PMCID: PMC4981359

Genes

STXBP2
MAF
SRSF1
SRSF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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