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Article

Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Jun 2012

Szalkowski Caitlin E, Fiondella Christopher G, Galaburda Albert M, Rosen Glenn D, Loturco Joseph J, Fitch R Holly

Abstract excerpt

Within the last decade several genes have been identified as candidate risk genes for developmental dyslexia. Recent research using animal models and embryonic RNA interference (RNAi) has shown that a subset of the candidate dyslexia risk genes--DYX1C1, ROBO1, DCDC2, KIAA0319--regulate critical parameters of neocortical development, such as neuronal migration. For example, embryonic disruption of the rodent...

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Identifiers

PMID: 22326444
DOI: 10.1016/j.ijdevneu.2012.01.009
PMCID: PMC3516384

Genes

DCDC2
ROBO1

Provenance

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