Article
A reverse genetic approach identifies an ancestral frameshift mutation in RP1 causing recessive progressive retinal degeneration in European cattle breeds.
Genetics, selection, evolution : GSE - 10 Aug 2016
Michot Pauline, Chahory Sabine, Marete Andrew, Grohs Cécile, Dagios Dimitri, Donzel Elise, Aboukadiri Abdelhak, Deloche Marie-Christine, Allais-Bonnet Aurélie, Chambrial Matthieu, Barbey Sarah, Genestout Lucie, Boussaha Mekki, Danchin-Burge Coralie, Fritz Sébastien, Boichard Didier, Capitan Aurélien
Abstract excerpt
BACKGROUND: Domestication and artificial selection have resulted in strong genetic drift, relaxation of purifying selection and accumulation of deleterious mutations. As a consequence, bovine breeds experience regular outbreaks of recessive genetic defects which might represent only the tip of the iceberg since their detection depends on the observation of affected animals with distinctive symptoms. Thus,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.