A Novel Mutation in the DNA Binding Domain of NFKB is Associated with Speckled Leukoplakia.

Abstract excerpt

BACKGROUND: Activation and inactivation of nuclear factor of kappa light chain gene enhancer in B cells (NFKB) is tightly regulated to ensure effective onset and cessation of defensive inflammatory signaling. However, mutations within NFKB, or change in activation and inactivation molecules have been reported in a few cancers. Although oral squamous cell carcinoma is one of the most prevalent forms of cancer in...

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