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Article

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases.

PloS one - 1 Jan 2016

Verma Anurag, Basile Anna O, Bradford Yuki, Kuivaniemi Helena, Tromp Gerard, Carey David, Gerhard Glenn S, Crowe James E, Ritchie Marylyn D, Pendergrass Sarah A

Abstract excerpt

We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories. We selected variants within genes encoding critical factors in the immune system and variants with known associations with autoimmunity. To define case/control status for EHR...

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Identifiers

PMID: 27508393
DOI: 10.1371/journal.pone.0160573
PMCID: PMC4980020

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