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Article

HNO suppresses LPS-induced inflammation in BV-2 microglial cells via inhibition of NF-κB and p38 MAPK pathways.

Pharmacological research - 1 Sept 2016

Zhou Yebo, Wu Zhiyuan, Cao Xu, Ding Lei, Wen ZhengShun, Bian Jin-Song

Abstract excerpt

Both hydrogen sulfide (H2S) and nitric oxide (NO) are important gaseous mediators. We and others previously reported that these two gases react with each other to generate a new mediator, nitroxyl (HNO), and regulate cardiovascular functions. In this study, we demonstrated for the first time that the interaction between the two gases also existed in microglia. The biological functions of HNO in microglial cells...

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Identifiers

PMID: 27507578
DOI: 10.1016/j.phrs.2016.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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