Article
Potent anti-inflammatory effects of an H2 S-releasing naproxen (ATB-346) in a human model of inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2021
Glanville James R W, Jalali Parinaaz, Flint Julia D, Patel Amit A, Maini Alexander A, Wallace John L, Hosin Ali A, Gilroy Derek W
Abstract excerpt
ATB-346 is a hydrogen sulfide-releasing non-steroidal anti-inflammatory drug (H2 S-NSAID) derived from naproxen, which in preclinical studies has been shown to have markedly reduced gastrointestinal adverse effects. However, its anti-inflammatory properties in humans compared to naproxen are yet to be confirmed. To test this, we used a dermal model of acute inflammation in healthy, human volunteers, triggered by...
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