Article

Combinatorial genomic biomarkers associated with high response in IgE-dependent human mast cell degranulation

2024-06-10

Abstract excerpt

<h4>Background: </h4> Mast cells are the major effector cells that mediate IgE-dependent allergic reactions via high-affinity IgE receptors. We sought to use integrated network analysis to identify genomic biomarkers associated with high response in IgE-mediated activation of primary human mast cells. <h4>Methods:</h4> Primary human mast cell cultures derived from a cohort of 262 normal donors were categorized int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e07fd0f-49c1-5d44-80f9-efacc0e9d0b8
DOI: 10.22541/au.171801550.02950828/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combinatorial genomic biomarkers associated with high response in IgE-dependent human mast cell degranulationDOI 10.22541/au.171801550.02950828/v1Read

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responsesSemantic proximity Read

IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cellsSemantic proximity Read

Analysis of Differentially expressed genes and Molecular pathways in Peanut Allergy Induced Dynamic Changes involved in Peanut-Specific Immune Responses: A Systematic and Bioinformatics ApproachSemantic proximity Read

A curated collection of transcriptome datasets to investigate the molecular mechanisms of immunoglobulin E-mediated atopic diseasesSemantic proximity Read

[A model for clinical study based on genome science--trials in disorders of the immune system and allergies].Semantic proximity Read

Identification of Novel Th2-Associated Genes in T Memory Responses to AllergensSemantic proximity Read

Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation.Semantic proximity Read

Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization.Semantic proximity Read

The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis.Semantic proximity Read

Identification of phenotype deterministic genes using systemic analysis of transcriptional response.Semantic proximity Read

Generation of a human allergic mast cell phenotype from CD133(+) stem cells.Semantic proximity Read

Generation of a Human Allergic Mast Cell Phenotype from CD133+ Stem Cells.Semantic proximity Read