Article
The Heidelberg Screen for Pattern Mutants of Drosophila: A Personal Account.
Annual review of cell and developmental biology - 6 Oct 2016
Wieschaus Eric, Nüsslein-Volhard Christiane
Abstract excerpt
In large-scale mutagenesis screens performed in 1979-1980 at the EMBL in Heidelberg, we isolated mutations affecting the pattern or structure of the larval cuticle in Drosophila. The 600 mutants we characterized could be assigned to 120 genes and represent the majority of such genes in the genome. These mutants subsequently provided a rich resource for understanding many fundamental developmental processes, such...
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