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Article

Somatic mosaicism in B cells of a patient with autosomal dominant hyper IgE syndrome.

European journal of immunology - 1 Oct 2016

Alcántara-Montiel Julio C, Staines-Boone Tamara, López-Herrera Gabriela, Berrón-Ruiz Laura, Borrego-Montoya Carlos R, Santos-Argumedo Leopoldo

Abstract excerpt

Hyper IgE syndrome (HIES) is characterized by recurrent skin abscesses, eczema, pneumonia, and high levels of serum IgE. Nonimmunologic manifestations of HIES include a characteristic face, pathologic dentition, scoliosis, bone alterations, hyperextensible joints, and vascular abnormalities. Somatic mosaicism is defined by the presence of two or more populations of cells with different genotypes in one...

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Identifiers

PMID: 27488252
DOI: 10.1002/eji.201546275

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