Article
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
The Journal of clinical investigation - 1 Apr 2013
Peng Hui, Jiang Xiaojun, Chen Yonglin, Sojka Dorothy K, Wei Haiming, Gao Xiang, Sun Rui, Yokoyama Wayne M, Tian Zhigang
Abstract excerpt
Liver natural killer (NK) cells were recently reported to possess memory-like properties in contact hypersensitivity (CHS) models. However, the phenotype and origin of these "memory" NK cells cannot be distinguished from other NK cell subpopulations. Here, we define the transcriptional, phenotypic, and functional features of liver NK cell subsets and their roles in mediating CHS. Liver NK cells can be divided...
Topics
- Adaptive Immunity
- Adoptive Transfer
- Animals
- Antigens, Differentiation
- Cell Differentiation
- Dermatitis, Contact
- Female
- Hematopoietic Stem Cells
- Immunologic Memory
- Integrin alpha1