Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.

Translational psychiatry - 2 Aug 2016

Brundin L, Sellgren C M, Lim C K, Grit J, Pålsson E, Landén M, Samuelsson M, Lundgren K, Brundin P, Fuchs D, Postolache T T, Traskman-Bendz L, Guillemin G J, Erhardt S

Abstract excerpt

Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of suicidal patients, levels of inflammatory cytokines and the kynurenine metabolite quinolinic acid (QUIN), an N-methyl-d-aspartate receptor agonist, are increased. The enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxy-Lyases
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Kynurenine

Share to Self-Injurious Behavior

Share to Suicidal Ideation

Share to Suicide, Attempted

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 27483383
DOI: 10.1038/tp.2016.133
PMCID: PMC5022080

Genes

ACMSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.PMID 27483383Read ↗

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative ReviewSemantic proximity Read ↗

The role of the kynurenine pathway in suicidality in adolescent major depressive disorderSemantic proximity Read ↗

Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatologySemantic proximity Read ↗

Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical ApplicationsSemantic proximity Read ↗

Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophreniaSemantic proximity Read ↗

Associations between Kynurenine pathway metabolites and cognitive dysfunction in major depressive disorderSemantic proximity Read ↗

Indoleamine 2,3-dioxygenase (IDO)-activity in Severe Psychiatric Disorders: A Systemic ReviewSemantic proximity Read ↗

Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases.Semantic proximity Read ↗

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity Read ↗

The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes.Semantic proximity Read ↗

Fight the Fire: Association of Cytokine Genomic Markers and Suicidal Behavior May Pave the Way for Future TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.