Article
Neuraminidase enhances in vitro expansion of human erythroid progenitors.
European cytokine network - 1 Jun 2016
Bodivit Gwellaouen, Chadebech Philippe, Vigon Isabelle, Yacia Azzedine, Roziers Nicolas Burin des, Pirenne France, Fichelson Serge
Abstract excerpt
In spite of recent key improvements, in vitro mass production of erythrocytes from human stem cells is still limited by difficulties in obtaining sufficient numbers of erythroid progenitors. In fact, such progenitors are as scarce in the bone marrow as in peripheral blood. We used a two-step culture model of human cord blood-derived erythroid progenitors in the presence or absence of high-purity neuraminidase, in...
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