Article
Nanofiber-mediated microRNA-126 delivery to vascular endothelial cells for blood vessel regeneration.
Acta biomaterialia - 1 Oct 2016
Zhou Fang, Jia Xiaoling, Yang Yang, Yang Qingmao, Gao Chao, Hu Suli, Zhao Yunhui, Fan Yubo, Yuan Xiaoyan
Abstract excerpt
UNLABELLED: As manipulation of gene expression by virtue of microRNAs (miRNAs) is one of the emerging strategies for cardiovascular disease remedy, local delivery of miRNAs to a specific vascular tissue is challenging. In this work, we developed an efficient delivery system composed of electrospun fibrous membranes and target carriers for the intracellular delivery of miRNA-126 (miR-126) to vascular endothelial...
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