Article
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.
Cell death & disease - 28 Jul 2016
Di Siena S, Gimmelli R, Nori S L, Barbagallo F, Campolo F, Dolci S, Rossi P, Venneri M A, Giannetta E, Gianfrilli D, Feigenbaum L, Lenzi A, Naro F, Cianflone E, Mancuso T, Torella D, Isidori A M, Pellegrini M
Abstract excerpt
The role of endogenous c-Kit receptor activation on cardiac cell homeostasis and repair remains largely unexplored. Transgenic mice carrying an activating point mutation (TgD814Y) in the kinase domain of the c-Kit gene were generated. c-Kit(TgD814Y) receptor was expressed in the heart during embryonic development and postnatal life, in a similar timing and expression pattern to that of the endogenous gene, but...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.