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Article

Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy.

Genes and immunity - 1 Sept 2016

Hoshino A, Saitoh M, Miyagawa T, Kubota M, Takanashi J-I, Miyamoto A, Tokunaga K, Oka A, Mizuguchi M

Abstract excerpt

Acute necrotizing encephalopathy (ANE) is a rare and severe syndrome of acute encephalopathy triggered by viral infections. Cytokine storm is considered as the main pathogenetic mechanism of ANE. ANE is prevalent in East Asia, suggesting the association of host genetic factors. To elucidate the genetic background of Japanese ANE, we examined genotypes of human leukocyte antigen (HLA)-A, C, B, DRB1, DQB1 and DPB1...

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Identifiers

PMID: 27467284
DOI: 10.1038/gene.2016.32

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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