Article
Homology-Independent Integration of Plasmid DNA into the Zebrafish Genome.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Auer Thomas O, Del Bene Filippo
Abstract excerpt
Targeting nucleases like zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) system have revolutionized genome-editing possibilities in many model organisms. They allow the generation of loss-of-function alleles by the introduction of double-strand breaks at defined sites within...
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