Article
Frequency of epidermal growth factor receptor mutations in Jordanian lung adenocarcinoma patients at diagnosis.
Journal of cancer research and therapeutics - 1 Jan 2000
Obeidat Natheir, Awidi Abdalla, Ababneh Nidaa, Shomaf Maha, Al-Adaily Tariq, Jaber Mohammad, Al-Khateeb Mohammad, Abbasi Salah
Abstract excerpt
BACKGROUND: Somatic mutations of the epidermal growth factor receptor (EGFR) gene have been associated with tumor response to tyrosine kinase inhibitors (TKIs) and favorable outcome in patients with non-small-cell lung cancer (NSCLC). The activating mutations that confer sensitivity to EGFR TKIs are present in the TK domain of the EGFR gene. This study aims to report on the prevalence of EGFR mutations in NSCLC...
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