Article
Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genotype conferring pyrethroid resistance in Aedes aegypti in Thailand.
Parasites & vectors - 26 Jul 2016
Plernsub Suriya, Saingamsook Jassada, Yanola Jintana, Lumjuan Nongkran, Tippawangkosol Pongsri, Sukontason Kom, Walton Catherine, Somboon Pradya
Abstract excerpt
BACKGROUND: Mutation in the voltage-gated sodium channel gene that results in knockdown resistance (kdr), is a major mechanism of pyrethroid resistance in several mosquito species. In Aedes aegypti, V1016G (occurring with and without S989P) and F1534C mutations are common and widely distributed throughout Asia. The G1016 allele is known to be associated with resistance to type I and II pyrethroids. The C1534...
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