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Article

GATA binding protein 2 overexpression is associated with poor prognosis in KRAS mutant colorectal cancer.

Oncology reports - 1 Sept 2016

Xu Kai, Wang Jiayuan, Gao Jing, Di Jiabo, Jiang Beihai, Chen Lei, Wang Zaozao, Wang Aidong, Wu Fan, Wu Wei, Shen Lin, Su Xiangqian

Abstract excerpt

Colorectal cancer (CRC) is one of the most lethal cancers worldwide. Mutations in KRAS occur with the frequency of 30-50% in CRC leading to decreased therapeutic response to anti-epidermal growth factor receptor (EGFR) agents. Recently GATA2 was proven to be essential in the survival of KRAS mutant non-small cell lung cancer (NSCLC) cells. However, the association between KRAS mutation and GATA2 expression in CRC...

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Source

Identifiers

PMID: 27460045
DOI: 10.3892/or.2016.4961

Genes

GATA2
KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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