Article
FOXP2/SOS1/AKT negative feedback loop inhibits cell proliferation in KRAS-mutant colorectal cancer.
Apoptosis : an international journal on programmed cell death - 1 Oct 2025
Liu Jinpu, Wang Yayun, Liu Yuya, Mei Hanwei, Zhang Qiaonan, Gao Zhanhua, Zhang Miao, Yang Zhen, Wang Huaqing, Qiu Minghan
Abstract excerpt
FOXP2, a member of the Forkhead box transcription factor family, has been implicated in diverse biological processes and malignancies. However, its role in colorectal cancer (CRC), particularly in the context of KRAS mutations, remains poorly defined. Here, we analyzed FOXP2 expression in CRC datasets and clinical specimens, and conducted functional assays-including colony formation, cell viability, EdU...
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