Article
Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.
International journal of cancer - 15 Nov 2016
Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Tanaka Haruyoshi, Shimizu Dai, Shibata Masahiro, Takami Hideki, Hayashi Masamichi, Iwata Naoki, Niwa Yukiko, Yamada Suguru, Fujii Tsutomu, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro
Abstract excerpt
Prediction of tumor recurrence after curative resection is critical for determining the prognosis of patients with gastric cancer (GC). The initiation and progression of GC are associated with inappropriate immune responses caused by chronic inflammation of the gastric mucosa. To identify immunoregulatory molecules involved in GC progression, GC cell lines and 200 pairs of tumor and normal tissues from patients...
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