Article
Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia.
Leukemia research - 1 May 2011
Deeb George, Vaughan Mary M, McInnis Ian, Ford Laurie Ann, Sait Sheila N J, Starostik Petr, Wetzler Meir, Mashtare Terry, Wang Eunice S
Abstract excerpt
We examined the predictive impact of HIF-1α protein expression on clinical outcome of 84 normal karyotype acute myeloid leukemia (NK-AML) patients (median age 66.5 years) at our institute. Thirty percent of NK-AML cells expressed cytoplasmic HIF-1α. In univariate analysis, low HIF-1α (≤ 5%, n = 66) was associated with improved event-free survival (p = 0.0453, HR = 0.22). Multivariate analysis incorporating age,...
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