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Article

Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.

Virchows Archiv : an international journal of pathology - 1 Jul 2021

Legrand Mélanie, Jourdan Marie-Lise, Tallet Anne, Collin Christine, Audard Virginie, Larousserie Frédérique, Aubert Sébastien, Gomez-Brouchet Anne, Bouvier Corinne, de Pinieux Gonzague

Abstract excerpt

Nodular fasciitis, primary aneurysmal bone cyst, myositis ossificans, and their related lesions are benign tumors that share common histological features and a chromosomal rearrangement involving the ubiquitin-specific peptidase 6 (USP6) gene. The identification of an increasing number of new partners implicated in USP6 rearrangements demonstrates a complex tumorogenesis of this tumor spectrum. In this study on a...

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PMID: 33558945
DOI: 10.1007/s00428-021-03047-z

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