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Article

Zoledronate treatment has different effects in mouse strains with contrasting baseline bone mechanical phenotypes.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Dec 2016

Aref M W, McNerny E M B, Brown D, Jepsen K J, Allen M R

Abstract excerpt

Two strains of mice with distinct bone morphologies and mechanical properties were treated with zoledronate. Our results show a different response to drug treatment in the two strains providing evidence that baseline properties of structure/material may influence response to zoledronate. INTRODUCTION: Bisphosphonates are highly effective in reducing fracture risk, yet some individuals treated with these agents...

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Identifiers

PMID: 27439372
DOI: 10.1007/s00198-016-3701-9
PMCID: PMC5543625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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