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Article

Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2008

Jepsen Karl J, Price Christopher, Silkman Lee J, Nicholls Fred H, Nasser Phillip, Hu Bin, Hadi Nicole, Alapatt Michael, Stapleton Stephanie N, Kakar Sanjeev, Einhorn Thomas A, Gerstenfeld Louis C

Abstract excerpt

These studies examined how genetic differences that regulate architectural and bone material properties would be expressed during fracture healing and determine whether any of these features would affect rates of healing as defined by regain of strength. Controlled fractures were generated in three inbred strains of mice: A/J, C57Bl/6J (B6), and C3H/HeJ (C3H). Both the A/J and B6 strains showed faster healing...

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Identifiers

PMID: 18348700
DOI: 10.1359/jbmr.080317
PMCID: PMC2650253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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