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Article

Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2016

Kwon SooJin, Ki Soo Mi, Park Sang Eon, Kim Min-Jeong, Hyung Brian, Lee Na Kyung, Shim Sangmi, Choi Byung-Ok, Na Duk L, Lee Ji Eun, Chang Jong Wook

Abstract excerpt

The role of Wharton's jelly-derived human mesenchymal stem cells (WJ-MSCs) in inhibiting muscle cell death has been elucidated in this study. Apoptosis induced by serum deprivation in mouse skeletal myoblast cell lines (C2C12) was significantly reduced when the cell lines were cocultured with WJ-MSCs. Antibody arrays indicated high levels of chemokine (C motif) ligand (XCL1) secretion by cocultured WJ-MSCs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27434589
DOI: 10.1038/mt.2016.125
PMCID: PMC5113102

Genes

XCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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