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Article

Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis

25 Mar 2022

Abstract excerpt

Activin A (ActA) is considered to play a major role in cancer-induced cachexia (CC). Indeed, circulating ActA levels are elevated and predict survival in patients with CC. However, the mechanisms by which ActA mediates CC development and in particular skeletal muscle (SM) atrophy in humans are not yet fully understood. In this work, we aimed to investigate the effects of ActA on human SM and in mouse models of...

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PMID: 35406681
DOI: 10.3390/cells11071119

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