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Article

Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy.

The Journal of clinical investigation - 1 Dec 2004

Girgenrath Mahasweta, Dominov Janice A, Kostek Christine A, Miller Jeffrey Boone

Abstract excerpt

The most common form of human congenital muscular dystrophy (CMD) is caused by mutations in the laminin-alpha2 gene. Loss of laminin-alpha2 function in this autosomal recessive type 1A form of CMD results in neuromuscular dysfunction and, often, early death. Laminin-alpha2-deficient skeletal muscles in both humans and mice show signs of muscle cell death by apoptosis. To examine the significance of apoptosis in...

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Source

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Identifiers

PMID: 15578095
DOI: 10.1172/JCI22928
PMCID: PMC529286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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