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Article

Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets.

Pharmaceutical research - 1 Nov 2016

Cory Theodore J, He Hui, Winchester Lee C, Kumar Santosh, Fletcher Courtney V

Abstract excerpt

PURPOSE: Macrophages are an important cellular reservoir in HIV, and exist in two phenotypically dissimilar subsets, the pro-inflammatory M1 phenotype, and the anti-inflammatory M2 phenotype. The role of these two subsets is uncertain. We hypothesized that differences in drug efflux transporters exist between the subsets, which would result in altered intracellular drug concentrations between these cells....

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PMID: 27431863
DOI: 10.1007/s11095-016-1998-x
PMCID: PMC5042840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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