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Article

HIV-1 Env-chemokine receptor interactions in primary human macrophages: entry and beyond.

Research initiative, treatment action : RITA - 1 Jan 2003

Collman Ronald G

Abstract excerpt

While HIV has subverted the chemokine receptors CCR5 and CXCR4 for its own use as an entry co-receptor, their normal functions are to transduce signals in response to extracellular ligands. Our lab is interested in understanding how HIV-1 glycoprotein 120 (gp120) may activate intracellular signals through these receptors in primary human macrophages, and how these responses may contribute to pathogenesis. Our...

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Share to Gene Products, env
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Membrane Fusion

Share to Polymorphism, Genetic

Share to Receptors, CCR5

Share to Receptors, CXCR4

Source

Identifiers

PMID: 12845769

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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