Article
Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.
Scientific reports - 18 Jul 2016
Perruolo Giuseppe, Viggiano Davide, Fiory Francesca, Cassese Angela, Nigro Cecilia, Liotti Antonietta, Miele Claudia, Beguinot Francesco, Formisano Pietro
Abstract excerpt
Neurological abnormalities, such as Parkinson-like disorders (PlD), are often co-morbidities of Type 2 Diabetic (T2D) patients, although the epidemiological link between these two disorders remains controversial. The PED/PEA-15 protein represents a possible candidate linking T2D and PD, because it is increased in subjects with T2D and is highly expressed in the brain. To test this hypothesis, we have analyzed the...
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