Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The serine protease TMPRSS6 is required to sense iron deficiency.

Science (New York, N.Y.) - 23 May 2008

Du Xin, She Ellen, Gelbart Terri, Truksa Jaroslav, Lee Pauline, Xia Yu, Khovananth Kevin, Mudd Suzanne, Mann Navjiwan, Moresco Eva Marie Y, Beutler Ernest, Beutler Bruce

Abstract excerpt

Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp in response to infection or high levels of iron. However, mechanism(s) of Hamp suppression during iron depleti...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Cationic Peptides
Share to Hepcidins
Share to Iron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron Deficiencies

Share to Mice, Mutant Strains

Share to Mice, Transgenic

Share to Serine Endopeptidases

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 18451267
DOI: 10.1126/science.1157121
PMCID: PMC2430097

Genes

TMPRSS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18451267-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The serine protease TMPRSS6 is required to sense iron deficiency.PMID 18451267Read ↗

Iron-deficiency anemia secondary to mutations in genes controlling hepcidin.Semantic proximity Read ↗

Role of matriptase-2 (TMPRSS6) in iron metabolism.Semantic proximity Read ↗

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6.Semantic proximity Read ↗

TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron HomeostasisSemantic proximity Read ↗

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individualsSemantic proximity Read ↗

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron.Semantic proximity Read ↗

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.Semantic proximity Read ↗

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.Semantic proximity Read ↗

Iron-refractory iron deficiency anemia.Semantic proximity Read ↗

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.Semantic proximity Read ↗

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasisSemantic proximity Read ↗

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.