A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.

doi:10.1002/ijc.30274

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.

International journal of cancer - 15 Dec 2016

Lee Alice W, Bomkamp Ashley, Bandera Elisa V, Jensen Allan, Ramus Susan J, Goodman Marc T, Rossing Mary Anne, Modugno Francesmary, Moysich Kirsten B, Chang-Claude Jenny, Rudolph Anja, Gentry-Maharaj Aleksandra, Terry Kathryn L, Gayther Simon A, Cramer Daniel W, Doherty Jennifer A, Schildkraut Joellen M, Kjaer Susanne K, Ness Roberta B, Menon Usha, Berchuck Andrew, Mukherjee Bhramar, Roman Lynda, Pharoah Paul D, Chenevix-Trench Georgia, Olson Sara, Hogdall Estrid, Wu Anna H, Pike Malcolm C, Stram Daniel O, Pearce Celeste Leigh

Abstract excerpt

Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by genome-wide association studies. The interplay among these loci, ET use and ovarian cancer risk has yet to be evaluated. We analyzed data from 1,414 serous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Estrogen Replacement Therapy

Share to Gene-Environment Interaction

Share to Menopause

Share to Ovarian Neoplasms

Share to Population Surveillance

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 27420401
DOI: 10.1002/ijc.30274
PMCID: PMC5500237

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.PMID 27420401Read ↗

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".Semantic proximity Read ↗

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.Semantic proximity Read ↗

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.Semantic proximity Read ↗

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.Semantic proximity Read ↗

Human TERT promoter polymorphism rs2853669 is associated with cancers: an updated meta-analysis.Semantic proximity Read ↗

Decoding the significance of TERT gene in Polycystic Ovary Syndrome: From molecular mechanisms to emerging diagnostic and therapeutic strategies.Semantic proximity Read ↗

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.Semantic proximity Read ↗

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.Semantic proximity Read ↗

ESR1 , WT1 , WNT4, ATM and TERT loci are major contributors to uterine leiomyoma predispositionSemantic proximity Read ↗

Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76,108 Cases and 134,215 Controls.Semantic proximity Read ↗

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.Semantic proximity Read ↗

DNA hypermethylation within TERT promoter upregulates TERT expression in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.