Article
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
PLoS genetics - 8 Jul 2010
Johnatty Sharon E, Beesley Jonathan, Chen Xiaoqing, Macgregor Stuart, Duffy David L, Spurdle Amanda B, deFazio Anna, Gava Natalie, Webb Penelope M, Rossing Mary Anne, Doherty Jennifer Anne, Goodman Marc T, Lurie Galina, Thompson Pamela J, Wilkens Lynne R, Ness Roberta B, Moysich Kirsten B, Chang-Claude Jenny, Wang-Gohrke Shan, Cramer Daniel W, Terry Kathryn L, Hankinson Susan E, Tworoger Shelley S, Garcia-Closas Montserrat, Yang Hannah, Lissowska Jolanta, Chanock Stephen J, Pharoah Paul D, Song Honglin, Whitemore Alice S, Pearce Celeste L, Stram Daniel O, Wu Anna H, Pike Malcolm C, Gayther Simon A, Ramus Susan J, Menon Usha, Gentry-Maharaj Aleksandra, Anton-Culver Hoda, Ziogas Argyrios, Hogdall Estrid, Kjaer Susanne K, Hogdall Claus, Berchuck Andrew, Schildkraut Joellen M, Iversen Edwin S, Moorman Patricia G, Phelan Catherine M, Sellers Thomas A, Cunningham Julie M, Vierkant Robert A, Rider David N, Goode Ellen L, Haviv Izhak, Chenevix-Trench Georgia
Abstract excerpt
We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes in...
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