Article
Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer.
Scientific reports - 15 Jul 2016
Bi Haoran, Tian Tian, Zhu Lin, Zhou Haibo, Hu Hanqing, Liu Yanhong, Li Xia, Hu Fulan, Zhao Yashuang, Wang Guiyu
Abstract excerpt
Given that E3 ubiquitin ligases (E3) regulate specific protein degradation in many cancer-related biological processes. E3 copy number variation (CNV) may affect the development and prognosis of colorectal cancer (CRC). Therefore, we detected CNVs of five E3 genes in 518 CRC patients and 518 age, gender and residence matched controls in China, and estimated the association between E3 gene CNVs and CRC risk and...
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