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Article

Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers

11 Jul 2016

Abstract excerpt

BACKGROUND: Down syndrome incidence in humans increases dramatically with maternal age. This is mainly the result of increased meiotic errors, but factors such as differences in abortion rate may play a role as well. Since the meiotic error rate increases almost exponentially after a certain age, its contribution to the overall incidence aneuploidy may mask the contribution of other processes. RESULTS: To focus...

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PMID: 27401751
DOI: 10.1186/s12863-016-0412-3

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