Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C.

doi:10.1016/j.ijid.2016.07.003

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Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2016

Sargin Altunok Elif, Sayan Murat, Akhan Sila, Aygen Bilgehan, Yildiz Orhan, Tekin Koruk Suda, Mistik Resit, Demirturk Nese, Ural Onur, Kose Şükran, Aynioglu Aynur, Korkmaz Fatime, Ersoz Gülden, Tuna Nazan, Ayaz Celal, Karakecili Faruk, Keten Derya, Inan Dilara, Yazici Saadet, Koculu Safiye, Yildirmak Taner

Abstract excerpt

BACKGROUND: Drug resistance development is an expected problem during treatment with protease inhibitors (PIs), this is largely due to the fact that Pls are low-genetic barrier drugs. Resistance-associated variants (RAVs) however may also occur naturally, and prior to treatment with Pls, the clinical impact of this basal resistance remains unknown. In Turkey, there is yet to be an investigation into the hepatitis...

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PMID: 27401586
DOI: 10.1016/j.ijid.2016.07.003

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